Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy
Specific and effective preventive treatment for diabetic retinopathy (DR) is presently unavailable, mostly because the early stages of the complication have been, until recently, poorly understood. The recent demonstration that the vascular phase of DR is preceded and possibly caused by the neurodeg...
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Frontiers Media S.A.,
2022-09-01T00:00:00Z.
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| 001 | doaj_aa3e62fe4b6c49e9acc02bcd7081a9f7 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Gianpaolo Zerbini |e author |
| 700 | 1 | 0 | |a Silvia Maestroni |e author |
| 700 | 1 | 0 | |a Letizia Leocani |e author |
| 700 | 1 | 0 | |a Letizia Leocani |e author |
| 700 | 1 | 0 | |a Andrea Mosca |e author |
| 700 | 1 | 0 | |a Andrea Mosca |e author |
| 700 | 1 | 0 | |a Michela Godi |e author |
| 700 | 1 | 0 | |a Renata Paleari |e author |
| 700 | 1 | 0 | |a Renata Paleari |e author |
| 700 | 1 | 0 | |a Arianna Belvedere |e author |
| 700 | 1 | 0 | |a Daniela Gabellini |e author |
| 700 | 1 | 0 | |a Paola Tirassa |e author |
| 700 | 1 | 0 | |a Valerio Castoldi |e author |
| 700 | 1 | 0 | |a Ilaria Viganò |e author |
| 700 | 1 | 0 | |a Silvia Galbiati |e author |
| 700 | 1 | 0 | |a Valentina Turco |e author |
| 700 | 1 | 0 | |a Alessandro Lambiase |e author |
| 700 | 1 | 0 | |a Paolo Rama |e author |
| 700 | 1 | 0 | |a Paolo Rama |e author |
| 245 | 0 | 0 | |a Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy |
| 260 | |b Frontiers Media S.A., |c 2022-09-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.1015522 | ||
| 520 | |a Specific and effective preventive treatment for diabetic retinopathy (DR) is presently unavailable, mostly because the early stages of the complication have been, until recently, poorly understood. The recent demonstration that the vascular phase of DR is preceded and possibly caused by the neurodegeneration of retinal ganglion cells suggests that DR could, at least theoretically, be prevented through an early neuroprotective approach. The aims of our study were to clarify the natural history of diabetes-driven retinal neurodegeneration and to verify the possibility to prevent DR using topical nerve growth factor (NGF). The results of the study show that retinal neurodegeneration, characterized by the loss of retinal ganglion cells represents a relatively early phenomenon of diabetes (between 5 and 16 weeks of age), which tends to be self-limiting in the long run. Neurodegeneration is followed by the development of DR-related vascular dysfunctions, as confirmed by the development of acellular capillaries and the loss of retinal pericytes. Both retinal neurodegeneration and subsequent vascular dysfunction can be successfully prevented by topical NGF administration. These findings suggest that: 1) The first stage of DR consists in a self-limiting retinal neurodegeneration 2) The demonstrated effectiveness of topical NGF in the prevention of DR could be rapidly translated into clinical practice. | ||
| 546 | |a EN | ||
| 690 | |a diabetic retinopathy | ||
| 690 | |a nerve growth factor | ||
| 690 | |a prevention | ||
| 690 | |a neurodegeneration | ||
| 690 | |a topical treatment | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.1015522/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/aa3e62fe4b6c49e9acc02bcd7081a9f7 |z Connect to this object online. |