Characterization of Carbapenem-Resistant <i>K. Pneumoniae</i> Isolated from Intensive Care Units of Zagazig University Hospitals
The advent of carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) poses a significant challenge to public health, as carbapenems are typically employed as a last resort to treat nosocomial infections caused by such organisms, especially in intensive care units (ICUs). This study aim...
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| Main Authors: | , , , |
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| Format: | Book |
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MDPI AG,
2022-08-01T00:00:00Z.
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| Summary: | The advent of carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) poses a significant challenge to public health, as carbapenems are typically employed as a last resort to treat nosocomial infections caused by such organisms, especially in intensive care units (ICUs). This study aims to characterize the CRKP isolated from patients admitted to the Zagazig University Hospitals (ZUHs) ICU in Egypt. About 56.2%, 41.0%, and 32.4% of the isolates indicated the presence of <i>bla</i><sub>NDM</sub>, <i>bla</i><sub>OXA-48</sub>, and <i>bla</i><sub>KPC</sub>, respectively. Carbapenemase-encoding genes were found in many isolates, and <i>bla</i><sub>NDM</sub> was the most predominant gene. Nevertheless, this situation has become a heavy burden in developing countries, including Egypt, and is associated with substantial morbidity, mortality, and increased healthcare expenses. |
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| Item Description: | 10.3390/antibiotics11081108 2079-6382 |