Brain Abscess as Severe Presentation of Specific Granule Deficiency

• Main Authors: Maria Leszcynska (Author), Bhumika Patel (Author), Matthew Morrow (Author), Wil Chamizo (Author), Gerald Tuite (Author), David M. Berman (Author), Kevin Potthast (Author), Amy P. Hsu (Author), Steven M. Holland (Author), Jennifer W. Leiding (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe invasive infections such as brain abscess in a child should prompt an immune evaluation. Specific granule deficiency (SGD) is a rare morphologic neutrophil granular defect characterized by reduced granules within neutrophils, absence of granule proteins, and bilobed nuclei. Patients are susce...