Mining a cathepsin inhibitor library for new antiparasitic drug leads.

• Main Authors: Kenny K H Ang (Author), Joseline Ratnam (Author), Jiri Gut (Author), Jennifer Legac (Author), Elizabeth Hansell (Author), Zachary B Mackey (Author), Katarzyna M Skrzypczynska (Author), Anjan Debnath (Author), Juan C Engel (Author), Philip J Rosenthal (Author), James H McKerrow (Author), Michelle R Arkin (Author), Adam R Renslo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping sickness, Chagas' disease, and malaria. The homology of parasite cysteine proteases to the human cathepsins suggests that inhibitors origina...