Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration
Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson's disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have investigated the transport of bromocriptine through the blood-brain barrier...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2009-08-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_aaa3ac3a93c24b359f2f68f8ac206e1b | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Sarah Vautier |e author |
| 700 | 1 | 0 | |a Aline Milane |e author |
| 700 | 1 | 0 | |a Christine Fernandez |e author |
| 700 | 1 | 0 | |a Helene Chacun |e author |
| 700 | 1 | 0 | |a Lucette Lacomblez |e author |
| 700 | 1 | 0 | |a Robert Farinotti |e author |
| 245 | 0 | 0 | |a Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration |
| 260 | |b Frontiers Media S.A., |c 2009-08-01T00:00:00Z. | ||
| 500 | |a 10.18433/J3B596 | ||
| 500 | |a 1482-1826 | ||
| 520 | |a Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson's disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have investigated the transport of bromocriptine through the blood-brain barrier (BBB) in a MPTP model to understand the influence of the dopaminergic degeneration on ABCB1 and ABCG2. Results: We have shown that in MPTP treated mice, bromocriptine is widely distributed to brain (2.3-fold versus control, p | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacy & Pharmaceutical Sciences, Vol 12, Iss 2 (2009) | |
| 787 | 0 | |n https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/1521 | |
| 787 | 0 | |n https://doaj.org/toc/1482-1826 | |
| 856 | 4 | 1 | |u https://doaj.org/article/aaa3ac3a93c24b359f2f68f8ac206e1b |z Connect to this object online. |