Estrogen-like and tissue-selective effects of 7-methoxycoumarin from Ficus umbellata (Moraceae): an in vitro and in vivo study

• Главные авторы: Stéphane Zingue (Автор), Thomas Michel (Автор), Chantal Beatrice Magne Nde (Автор), Amstrong Nang Njuh (Автор), Julia Cisilotto (Автор), Derek Tantoh Ndinteh (Автор), Colin Clyne (Автор), Xavier Fernandez (Автор), Tânia Beatriz Creczynski-Pasa (Автор), Dieudonné Njamen (Автор)
• Формат: ‌
• Опубликовано: BMC, 2017-08-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract Background Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory...