Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.

• Main Authors: John K Thuita (Author), Kristina K Wolf (Author), Grace A Murilla (Author), Arlene S Bridges (Author), David W Boykin (Author), James N Mutuku (Author), Qiang Liu (Author), Susan K Jones (Author), Charles O Gem (Author), Shelley Ching (Author), Richard R Tidwell (Author), Michael Z Wang (Author), Mary F Paine (Author), Reto Brun (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infection. In response to this largely unmet need for...