Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds
Autophagy is a self-degradation process in which damaged proteins and organelles are engulfed into autophagosomes for digestion and eventually recycled for cellular metabolism to maintain intracellular homeostasis. Accumulating studies have reported that autophagy has the Janus role in cancer as a t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-08-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_ab081c312c444d2fb7ed7c625df5604b | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Lijuan Zhang |e author |
| 700 | 1 | 0 | |a Lijuan Zhang |e author |
| 700 | 1 | 0 | |a Yuxuan Zhu |e author |
| 700 | 1 | 0 | |a Yuxuan Zhu |e author |
| 700 | 1 | 0 | |a Jiahui Zhang |e author |
| 700 | 1 | 0 | |a Jiahui Zhang |e author |
| 700 | 1 | 0 | |a Lan Zhang |e author |
| 700 | 1 | 0 | |a Lu Chen |e author |
| 700 | 1 | 0 | |a Lu Chen |e author |
| 245 | 0 | 0 | |a Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds |
| 260 | |b Frontiers Media S.A., |c 2022-08-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.966012 | ||
| 520 | |a Autophagy is a self-degradation process in which damaged proteins and organelles are engulfed into autophagosomes for digestion and eventually recycled for cellular metabolism to maintain intracellular homeostasis. Accumulating studies have reported that autophagy has the Janus role in cancer as a tumor suppressor or an oncogenic role to promote the growth of established tumors and developing drug resistance. Importantly, cytoprotective autophagy plays a prominent role in many types of human cancers, thus inhibiting autophagy, and has been regarded as a promising therapeutic strategy for cancer therapy. Here, we focus on summarizing small-molecule compounds inhibiting the autophagy process, as well as further discuss other dual-target small-molecule compounds, combination strategies, and other strategies to improve potential cancer therapy. Therefore, these findings will shed new light on exploiting more small-molecule compounds inhibiting cytoprotective autophagy as candidate drugs for fighting human cancers in the future. | ||
| 546 | |a EN | ||
| 690 | |a autophagy | ||
| 690 | |a cytoprotective autophagy | ||
| 690 | |a small-molecule compound | ||
| 690 | |a inhibitor | ||
| 690 | |a cancer therapy | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.966012/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ab081c312c444d2fb7ed7c625df5604b |z Connect to this object online. |