Comparison of the effect of two combinations of myo-inositol and D-chiro-inositol in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial
The purpose of this study was to evaluate the effect of two doses of D-chiro-inositol (DCI) in combination with Myo-inositol (MYO) in women with PCOS undergoing ICSI. This was a multicenter controlled, randomized, double-blind parallel group study with two MYO-DCI formulations for 12 weeks. The stud...
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Taylor & Francis Group,
2019-08-01T00:00:00Z.
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| 001 | doaj_ab1ceaab77714bfe83c135f5f9a79abf | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Nicolas Mendoza |e author |
| 700 | 1 | 0 | |a Maria Paz Diaz-Ropero |e author |
| 700 | 1 | 0 | |a Miguel Aragon |e author |
| 700 | 1 | 0 | |a Vicente Maldonado |e author |
| 700 | 1 | 0 | |a Placido Llaneza |e author |
| 700 | 1 | 0 | |a Juan Lorente |e author |
| 700 | 1 | 0 | |a Raquel Mendoza-Tesarik |e author |
| 700 | 1 | 0 | |a Jose Maldonado-Lobon |e author |
| 700 | 1 | 0 | |a Monica Olivares |e author |
| 700 | 1 | 0 | |a Juristo Fonolla |e author |
| 245 | 0 | 0 | |a Comparison of the effect of two combinations of myo-inositol and D-chiro-inositol in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial |
| 260 | |b Taylor & Francis Group, |c 2019-08-01T00:00:00Z. | ||
| 500 | |a 10.1080/09513590.2019.1576620 | ||
| 500 | |a 1473-0766 | ||
| 500 | |a 0951-3590 | ||
| 520 | |a The purpose of this study was to evaluate the effect of two doses of D-chiro-inositol (DCI) in combination with Myo-inositol (MYO) in women with PCOS undergoing ICSI. This was a multicenter controlled, randomized, double-blind parallel group study with two MYO-DCI formulations for 12 weeks. The study group (SG) was administered 550 mg of MYO + 150 mg of DCI twice daily; the control group (CG) was administered 550 mg of MYO + 13.8 mg of DCI twice daily. The participants comprised 60 women with PCOS undergoing ICSI. At baseline, no differences were found between the two groups regarding age, BMI, HOMA-IR or testosterone levels. The pregnancy and live birth rates were significantly higher in the SG than in the CG (65.5 vs. 25.9 and 55.2 vs. 14.8, respectively) [risk ratio (RR) = 0.4; 95%CI (0.2, 0.79); p = .003 and RR = 0.27; 95%CI (0.10, 0.70); p = .002 respectively]. The risk of ovarian hyperstimulation syndrome (OHSS) was lower in the SG (3.44 vs. 18.5%, p = .07). The combination of MYO-DCI at high doses of DCI improves the pregnancy rates and reduces the risk of OHSS in women with PCOS undergoing ICSI. | ||
| 546 | |a EN | ||
| 690 | |a Myo-inositol | ||
| 690 | |a D-chiro-inositol | ||
| 690 | |a polycystic ovary syndrome | ||
| 690 | |a ICSI | ||
| 690 | |a pregnancy rate | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 690 | |a Diseases of the endocrine glands. Clinical endocrinology | ||
| 690 | |a RC648-665 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Gynecological Endocrinology, Vol 35, Iss 8, Pp 695-700 (2019) | |
| 787 | 0 | |n https://www.tandfonline.com/doi/10.1080/09513590.2019.1576620 | |
| 787 | 0 | |n https://doaj.org/toc/0951-3590 | |
| 787 | 0 | |n https://doaj.org/toc/1473-0766 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ab1ceaab77714bfe83c135f5f9a79abf |z Connect to this object online. |