pFOE or pFTOE as an Early Marker for Impaired Peripheral Microcirculation in Neonates
Background: Peripheral-muscle-fractional-oxygen-extraction (pFOE) and peripheral-muscle-fractional-tissue-oxygen-extraction (pFTOE) are often equated, since both parameters are measured with near-infrared-spectroscopy (NIRS) and estimate oxygen extraction in the tissue. The aim was to investigate th...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2022-06-01T00:00:00Z.
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| Summary: | Background: Peripheral-muscle-fractional-oxygen-extraction (pFOE) and peripheral-muscle-fractional-tissue-oxygen-extraction (pFTOE) are often equated, since both parameters are measured with near-infrared-spectroscopy (NIRS) and estimate oxygen extraction in the tissue. The aim was to investigate the comparability of both parameters and their potential regarding detection of impaired microcirculation. Methods: Term and preterm neonates with NIRS measurements of upper (UE) and lower extremities (LE) were included. pFOE was calculated out of peripheral-muscle-mixed-venous-saturation (pSvO<sub>2</sub>), measured with NIRS and venous occlusion, and arterial oxygen saturation (SpO<sub>2</sub>). pFTOE was calculated out of peripheral-muscle-tissue-oxygen-saturation and SpO<sub>2</sub>. Both parameters were compared using Wilcoxon-Signed-Rank-test and Bland-Altman plots. Results: 341 NIRS measurements were included. pFOE was significantly higher than pFTOE in both locations. Bland-Altman plots revealed limited comparability, especially with increasing oxygen extraction with higher values of pFOE compared to pFTOE. Conclusion: The higher pFOE compared to pFTOE suggests a higher potential of pFOE to detect impaired microcirculation, especially when oxygen extraction is elevated. |
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| Item Description: | 10.3390/children9060898 2227-9067 |