CHIP mutations affect the heat shock response differently in human fibroblasts and iPSC-derived neurons
C-terminus of HSC70-interacting protein (CHIP) encoded by the gene STUB1 is a co-chaperone and E3 ligase that acts as a key regulator of cellular protein homeostasis. Mutations in STUB1 cause autosomal recessive spinocerebellar ataxia type 16 (SCAR16) with widespread neurodegeneration manifesting as...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2020-10-01T00:00:00Z.
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