Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy

• Main Authors: T Golmohamadi (Author), A Nikzamir (Author), M Nakhjavani (Author), M Zahrai (Author), A Amirzargar (Author), R Saffari (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2006-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2251-6085
• Keywords: Angiotensin converting enzyme; Genetic polymorphism; Insertion/deletion; Public aspects of medicine; RA1-1270
• Source: Iranian Journal of Public Health, Vol 35, Iss 3, Pp 14-21 (2006)

Angiotensin I-converting Enzyme (ACE) gene polymorphism; genotype DD or D allele may be involved with an increased susceptibility to type 2 diabetes and diabetic nephropathy (DN). We examined the frequency of ACE gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without it) in Tehran, Iran. DNA was extracted from the white blood cells and the I/D polymorphism of the ACE gene was detected by PCR. The frequency of DD, ID and II genotypes in type 2 diabetic patients were 20%, 61.2% and 18.8%, and in patients with nephropathy 30.6%, 55.3%, 14.1%, respectively. The DD genotype of the DN group was higher than that of the type 2 diabetes patients (30.6% vs 20%, P=0.157, RR=1.3) and the control group (30.6% vs 14.3%, P=0.006, RR=2.9). The frequency of D allele in nephropathic patients was 58.2% as compared to the type 2 diabetic patients without nephropathy (50.5%) P=0.19, RR=1.16. The D allele frequency in the DN group was found slightly higher than of the type 2 diabetes (X2=0.684, OR=0.709, 95%CI: 0.313-1.606, P=0.408) which indicated the D allele was not associated with DN. It is suggested that DD genotype and D allele are not associated with diabetic nephropathy.