Cx3cr1 deficiency in mice attenuates hepatic granuloma formation during acute schistosomiasis by enhancing the M2-type polarization of macrophages

• Main Authors: Lin Ran (Author), Qilin Yu (Author), Shu Zhang (Author), Fei Xiong (Author), Jia Cheng (Author), Ping Yang (Author), Jun-Fa Xu (Author), Hao Nie (Author), Qin Zhong (Author), Xueli Yang (Author), Fei Yang (Author), Quan Gong (Author), Michal Kuczma (Author), Piotr Kraj (Author), Weikuan Gu (Author), Bo-Xu Ren (Author), Cong-Yi Wang (Author)
• Format: Book
• Published: The Company of Biologists, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute schistosomiasis is characterized by pro-inflammatory responses against tissue- or organ-trapped parasite eggs along with granuloma formation. Here, we describe studies in Cx3cr1−/− mice and demonstrate the role of Cx3cr1 in the pathoetiology of granuloma formation during acute schistosomiasis....