Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's Disease
Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer's disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases,...
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| Format: | Book |
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MDPI AG,
2021-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_ac02d7a633744e7fa4c3d57a67d425d5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Lidia Ciccone |e author |
| 700 | 1 | 0 | |a Jennifer Vandooren |e author |
| 700 | 1 | 0 | |a Susanna Nencetti |e author |
| 700 | 1 | 0 | |a Elisabetta Orlandini |e author |
| 245 | 0 | 0 | |a Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's Disease |
| 260 | |b MDPI AG, |c 2021-01-01T00:00:00Z. | ||
| 500 | |a 10.3390/ph14020086 | ||
| 500 | |a 1424-8247 | ||
| 520 | |a Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer's disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on natural marine and terrestrial compounds, as well as their ability to modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer's disease. | ||
| 546 | |a EN | ||
| 690 | |a MMP-2 | ||
| 690 | |a MMP-9 | ||
| 690 | |a Alzheimer's disease | ||
| 690 | |a AD | ||
| 690 | |a neurodegeneration | ||
| 690 | |a neuroinflammation | ||
| 690 | |a Medicine | ||
| 690 | |a R | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceuticals, Vol 14, Iss 2, p 86 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/1424-8247/14/2/86 | |
| 787 | 0 | |n https://doaj.org/toc/1424-8247 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ac02d7a633744e7fa4c3d57a67d425d5 |z Connect to this object online. |