Wilms tumor in childhood: Single centre retrospective study from the National Institute of Oncology of Rabat and literature review

Background: Wilms tumor is a very common renal malignancy in children. Prognosis has been improved dramatically during the last few decades because of multimodal treatment and successful sequential studies. Through a retrospective study conducted in the National Institute of Oncology of Rabat, conce...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Fadoua Rais (Author), Naoual Benhmidou (Author), Ghizlane Rais (Author), Hasnaa Loughlimi (Author), Fadila Kouhen (Author), Abdelhak Maghous (Author), Jihane Aarab (Author), Khadija Bellahammou (Author), Mouna Moukinebillah (Author), Mohamed Khattab (Author), Sanaa Chala (Author), Sanaa Elmejjaoui (Author), Tayeb Kebdani (Author), Hanan Elkacemi (Author), Noureddine Benjaafar (Author)
বিন্যাস: গ্রন্থ
প্রকাশিত: Elsevier, 2016-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Fadoua Rais  |e author 
700 1 0 |a Naoual Benhmidou  |e author 
700 1 0 |a Ghizlane Rais  |e author 
700 1 0 |a Hasnaa Loughlimi  |e author 
700 1 0 |a Fadila Kouhen  |e author 
700 1 0 |a Abdelhak Maghous  |e author 
700 1 0 |a Jihane Aarab  |e author 
700 1 0 |a Khadija Bellahammou  |e author 
700 1 0 |a Mouna Moukinebillah  |e author 
700 1 0 |a Mohamed Khattab  |e author 
700 1 0 |a Sanaa Chala  |e author 
700 1 0 |a Sanaa Elmejjaoui  |e author 
700 1 0 |a Tayeb Kebdani  |e author 
700 1 0 |a Hanan Elkacemi  |e author 
700 1 0 |a Noureddine Benjaafar  |e author 
245 0 0 |a Wilms tumor in childhood: Single centre retrospective study from the National Institute of Oncology of Rabat and literature review 
260 |b Elsevier,   |c 2016-08-01T00:00:00Z. 
500 |a 2468-1245 
500 |a 10.1016/j.phoj.2016.07.006 
520 |a Background: Wilms tumor is a very common renal malignancy in children. Prognosis has been improved dramatically during the last few decades because of multimodal treatment and successful sequential studies. Through a retrospective study conducted in the National Institute of Oncology of Rabat, concerning children with Wilms tumor treated following the International Society of Pediatric Oncology protocol (93-01) between 2005 and 2010, we report the experience of our institute in treatment of this malignancy. We analyze also the clinicopathologic and therapeutic aspects impacting the outcome results and compared to literature data. Results: Fifty-two patients with Wilms tumor treated in the department of radiotherapy after receiving chemotherapy and surgery at the department of hemato-oncology in children hospital of Rabat were enrolled. The main characteristic was the high prevalence of locally advanced and metastatic stages (32.6% of stage IV). With a median follow up of 54.8 months [20-79], we observed a complete response in 32 cases (61.5%), local recurrence in only one case (1.9%), metastatic relapse in 3 cases (5.8%), both local and metastatic recurrence in 3 cases (5.8%) and disease progression in 8 cases (15.4%). The mean duration of overall survival was 91.2 months. The estimated 2-year and 5-year overall survival were 78.7% and 70.1% and for metastatic patients 68.8% and 62.5% respectively. At univariate analysis several parameters were tested for survival, but only age, anaplasia, lymph node involvement, type of metastasis and response to treatment were found to significantly impact the overall survival. Outcome was better for localized tumors (stage I, II and III) compared with disseminated tumors (stage IV and V) combined. Also a better survival rate was found in the low and intermediate risk group compared to high risk, but not statistically significant. Conclusion: The relatively low outcome found in this series compared to literature can be mainly explained by the higher prevalence of metastatic disease compared to other series, but also by diagnosis and therapeutic delay, more likely because of bad socioeconomic conditions and lack of coordination between different operators. However, our results are nevertheless comparable to maghrebian series. Our department has established many procedures for improving the outcome and further studies are necessary to evaluate their efficiency. 
546 |a EN 
690 |a Wilms tumor 
690 |a Nephroblastoma 
690 |a Children 
690 |a Treatment 
690 |a Radiation therapy 
690 |a Outcome 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Pediatric Hematology Oncology Journal, Vol 1, Iss 2, Pp 28-34 (2016) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S2468124516300377 
787 0 |n https://doaj.org/toc/2468-1245 
856 4 1 |u https://doaj.org/article/ac1b4fa9b1094e6a9b14e15450029dce  |z Connect to this object online.