Quantification and Validation of a HPLC-UV Method for Simultaneous Analysis of Nitrosoamine Impurities (NDMA, NDEA and NDIPA) in Losartan

• Main Authors: Santosh Patil (Author), Rajeev Chadar (Author), Ashok Prasad (Author), Poonam Koppula (Author), Santhosh Koppula (Author)
• Format: Book
• Published: Krupanidhi College of Pharmacy, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Impurity profiling is an important aspect in drug therapy for its safety and efficacy. The study of impurities of sartans, the first line antihypertensive drugs, has become critical due to presence of cancer causing N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA) and N-nitrosodiisopropyl...