Formulation and Evaluation of Silymarin Microcrystals by In- Situ Micronization Technique
Silymarin (SM) is a plant extract obtained from Silybum marianum( milk thistle) . It is class II type drug according to Biopharmaceutics Classification System with low bioavailability due to its low solubility. Micro/nanonization during crystallization, surface modification and crystal structure mo...
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| Main Authors: | , |
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| Format: | Book |
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College of Pharmacy University of Baghdad,
2019-06-01T00:00:00Z.
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| Summary: | Silymarin (SM) is a plant extract obtained from Silybum marianum( milk thistle) . It is class II type drug according to Biopharmaceutics Classification System with low bioavailability due to its low solubility. Micro/nanonization during crystallization, surface modification and crystal structure modification may improve the dissolution rate of poorly water-soluble drugs. The aim of this study was to increase the water solubility and dissolution rate of SM by in-situ micronization using solvent change either by stirring or ultrasonic method. Stabilizers like Gelatin, PVP-K30, HPMC15, Pulullan were used to stabilize the prepared ultrafine crystals. Effect of type and concentration of hydrophilic polymer, solvent: antisolvent volume ratio and the effect of ultrasonic irradiation were studied. The prepared microcrystals were evaluated for their %yield, water solubility, crystals structure by XRD,DSC, and SEM. Particle size and dissolution rate were also tested . Silymarin microcrystals prepared by ultrasonic method and stabilized by 0.1%gelatin using 1:2 solvent: anti-solvent volume ratio showed the best results with particle size reduction from mean diameter of 1.5µm (untrated silymarin) to 0.43µm with uniform morphology and enhanced solubility and dissolution. |
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| Item Description: | 10.31351/vol28iss1pp1-16 2521-3512 1683-3597 |