Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model

• Main Authors: Susanne Jacobsson (Author), Daniel Golparian (Author), Joakim Oxelbark (Author), Emilie Alirol (Author), Francois Franceschi (Author), Tomas N. Gustafsson (Author), David Brown (Author), Arnold Louie (Author), George Drusano (Author), Magnus Unemo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antimicrobial resistance in Neisseria gonorrhoeae is threatening the treatment and control of gonorrhea globally, and new treatment options are imperative. Utilizing our dynamic in vitro hollow fiber infection model (HFIM), we examined the pharmacodynamics of the first-in-class spiropyrimidinetrione...