Genetic alterations and molecular mechanisms underlying hereditary intrahepatic cholestasis

• Main Authors: Shuying Xie (Author), Shizhang Wei (Author), Xiao Ma (Author), Ruilin Wang (Author), Tingting He (Author), Zhao Zhang (Author), Ju Yang (Author), Jiawei Wang (Author), Lei Chang (Author), Manyi Jing (Author), Haotian Li (Author), Xuelin Zhou (Author), Yanling Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hereditary cholestatic liver disease caused by a class of autosomal gene mutations results in jaundice, which involves the abnormality of the synthesis, secretion, and other disorders of bile acids metabolism. Due to the existence of a variety of gene mutations, the clinical manifestations of childr...