High-dose pulsed hyaluronidase for managing nasal skin necrosis following hyaluronic acid treatment in nasolabial folds: A case report

The growing popularity of soft tissue filler injections has brought attention to the associated risks, particularly vascular complications, and their treatments. This case report focuses on a 34-year-old female who developed nasal skin necrosis following hyaluronic acid (HA) filler injection for nas...

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Main Authors: Marcelo Germani (Author), Panmella Alegria (Author), Gabriela Giro (Author), Victor R.M. Munoz-Lora (Author)
Format: Book
Published: Elsevier, 2024-05-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Marcelo Germani  |e author 
700 1 0 |a Panmella Alegria  |e author 
700 1 0 |a Gabriela Giro  |e author 
700 1 0 |a Victor R.M. Munoz-Lora  |e author 
245 0 0 |a High-dose pulsed hyaluronidase for managing nasal skin necrosis following hyaluronic acid treatment in nasolabial folds: A case report 
260 |b Elsevier,   |c 2024-05-01T00:00:00Z. 
500 |a 2212-4268 
500 |a 10.1016/j.jobcr.2024.04.006 
520 |a The growing popularity of soft tissue filler injections has brought attention to the associated risks, particularly vascular complications, and their treatments. This case report focuses on a 34-year-old female who developed nasal skin necrosis following hyaluronic acid (HA) filler injection for nasolabial fold (NLF) enhancement. Despite the careful procedure, complications emerged rapidly, emphasizing the critical importance of prompt diagnosis and intervention. A total of 10,000 turbidity reducing units (TRU) of hyaluronidase (HSE) were administered in a high-dose pulsed manner, alongside hyperbaric oxygen therapy. The patient experienced a gradual but significant improvement over 60 days. This case underscores the need for constant vigilance in aesthetic medicine and the potential consequences of even minute HA amounts, exceeding zero, in causing severe vascular events. 
546 |a EN 
690 |a Hyaluronic acid 
690 |a Ischemia 
690 |a Necrosis 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Journal of Oral Biology and Craniofacial Research, Vol 14, Iss 3, Pp 339-341 (2024) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S2212426824000629 
787 0 |n https://doaj.org/toc/2212-4268 
856 4 1 |u https://doaj.org/article/ac72cac9cd9c4922b28d2ba74b38d725  |z Connect to this object online.