Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture
The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5-...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Hindawi Limited,
1993-01-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_ac76a2d39ebe45b698ef4c25dd6cfa8c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a C. Zoja |e author |
| 700 | 1 | 0 | |a A. Benigni |e author |
| 700 | 1 | 0 | |a G. Piccinini |e author |
| 700 | 1 | 0 | |a M. Figliuzzi |e author |
| 700 | 1 | 0 | |a L. Longaretti |e author |
| 700 | 1 | 0 | |a G. Remuzzi |e author |
| 245 | 0 | 0 | |a Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture |
| 260 | |b Hindawi Limited, |c 1993-01-01T00:00:00Z. | ||
| 500 | |a 0962-9351 | ||
| 500 | |a 1466-1861 | ||
| 500 | |a 10.1155/S0962935193000614 | ||
| 520 | |a The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis. | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Mediators of Inflammation, Vol 2, Iss 6, Pp 429-433 (1993) | |
| 787 | 0 | |n http://dx.doi.org/10.1155/S0962935193000614 | |
| 787 | 0 | |n https://doaj.org/toc/0962-9351 | |
| 787 | 0 | |n https://doaj.org/toc/1466-1861 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ac76a2d39ebe45b698ef4c25dd6cfa8c |z Connect to this object online. |