Intestinal SIRT3 overexpression in mice improves whole body glucose homeostasis independent of body weight

• Main Authors: Deepti Ramachandran (Author), Rosmarie Clara (Author), Shahana Fedele (Author), Junmin Hu (Author), Endre Lackzo (Author), Jing-Yi Huang (Author), Eric Verdin (Author), Wolfgang Langhans (Author), Abdelhak Mansouri (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Intestinal metabolism might play a greater role in regulating whole body metabolism than previously believed. We aimed to enhance enterocyte metabolism in mice and investigate if it plays a role in diet-induced obesity (DIO) and its comorbidities. Methods: Using the cre-loxP system, we ov...