Isolation, Identification, Anti-Inflammatory, and In Silico Analysis of New Lignans from the Resin of <i>Ferula sinkiangensis</i>

• Main Authors: Junchi Wang (Author), Qi Zheng (Author), Minghui Shi (Author), Huaxiang Wang (Author), Congzhao Fan (Author), Guoping Wang (Author), Yaqin Zhao (Author), Jianyong Si (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2023-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Resumo

<i>Ferula sinkiangensis</i> K. M. Shen (Apiaceae) is distributed in arid desert areas of Xinjiang, and its resin is a traditional Chinese medicine to treat gastrointestinal digestive diseases. To explore bioactive components from <i>F. sinkiangensis</i>, three new lignans and thirteen known components were isolated. The structural elucidation of the components was established utilizing spectroscopic analyses together with ECD calculations. Griess reaction results indicated new compounds <b>1</b> and <b>2</b> significantly decreased NO production in LPS-stimulated RAW 264.7 macrophages, and ELISA results indicated that they effectively attenuated LPS-induced inflammation by inhibiting TNF-α, IL-1β, and IL-6 expressions. The in silico approach confirmed that compound <b>1</b> docked into the receptors with strong binding energies of −5.84~−10.79 kcal/mol. In addition, compound <b>6</b> inhibited the proliferation of AGS gastric cancer cells with IC₅₀ values of 15.2 μM by suppressing the cell migration and invasion. This study disclosed that <i>F. sinkiangensis</i> might be a promising potential resource for bioactive components.

Descrição do item

10.3390/ph16101351
1424-8247