Formulation and Evaluation of Apigenin-Loaded Hybrid Nanoparticles
Apigenin (AGN) is a potent phytochemical with strong antioxidant and anticancer potential. But its therapeutic efficacy is limited due to its high lipophilic characteristics. Therefore, the present investigation aimed to develop AGN-loaded polymer-lipid hybrid nanoparticles (AGN-PLHNPs). Herein, we...
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2022-04-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
---|---|---|---|
001 | doaj_aca7a8c3d8fe4f18b830269e87b376a0 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Imran Kazmi |e author |
700 | 1 | 0 | |a Fahad A. Al-Abbasi |e author |
700 | 1 | 0 | |a Syed Sarim Imam |e author |
700 | 1 | 0 | |a Muhammad Afzal |e author |
700 | 1 | 0 | |a Muhammad Shahid Nadeem |e author |
700 | 1 | 0 | |a Hisham N. Altayb |e author |
700 | 1 | 0 | |a Sultan Alshehri |e author |
245 | 0 | 0 | |a Formulation and Evaluation of Apigenin-Loaded Hybrid Nanoparticles |
260 | |b MDPI AG, |c 2022-04-01T00:00:00Z. | ||
500 | |a 10.3390/pharmaceutics14040783 | ||
500 | |a 1999-4923 | ||
520 | |a Apigenin (AGN) is a potent phytochemical with strong antioxidant and anticancer potential. But its therapeutic efficacy is limited due to its high lipophilic characteristics. Therefore, the present investigation aimed to develop AGN-loaded polymer-lipid hybrid nanoparticles (AGN-PLHNPs). Herein, we successfully developed AGN-PLHNPs and optimized them by a 33-Box-Behnken de-sign. The poly (lactic-co-glycolic acid) (PLGA; coded as F1), phospholipon 90 G (PL-90G; coded as F2), and poloxamer 188 (P-188; coded as F3) were considered as the independent factors while particle size (PS; coded as R1), entrapment efficiency (%EE; R2), and cumulative drug release (%CDR; R3) were selected as dependent responses. The average PS, %EE, and %CDR of the AGN-PLHNPs were observed in the range of 101.93 nm to 175.26 nm, 58.35% to 81.14%, and 71.21% to 93.31%, respectively. The optimized AGN-PLHNPs revealed better homogeneity (poly-dispersity index < 0.2) and colloidal stability with high zeta potential (>25 mV). It also exhibited fast release in the initial 4 h after that sustained release up to 48 h of study. Moreover, the results of both DPPH as well as ABTS assays revealed significant improvement in the antioxidant activity. Furthermore, the optimized AGN-PLHNPs exhibited enhanced cytotoxicity efficacy against MCF-7 as well as MDA-MB-231 breast cancer cell lines. | ||
546 | |a EN | ||
690 | |a Apigenin | ||
690 | |a breast cancer | ||
690 | |a optimization | ||
690 | |a cytotoxicity study | ||
690 | |a antioxidant activity | ||
690 | |a Pharmacy and materia medica | ||
690 | |a RS1-441 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Pharmaceutics, Vol 14, Iss 4, p 783 (2022) | |
787 | 0 | |n https://www.mdpi.com/1999-4923/14/4/783 | |
787 | 0 | |n https://doaj.org/toc/1999-4923 | |
856 | 4 | 1 | |u https://doaj.org/article/aca7a8c3d8fe4f18b830269e87b376a0 |z Connect to this object online. |