Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women

Abstract Background The identification of variants in the nicotinic acetylcholine receptor (nAChR) subunit genes associated with smoking phenotypes are increasingly important for prevention and treatment of nicotine dependence. In the context of personalized medicine, the aims of this study were to...

Full description

Saved in:
Bibliographic Details
Main Authors: Paulo Roberto Xavier Tomaz (Author), Juliana Rocha Santos (Author), Jaqueline Scholz (Author), Tânia Ogawa Abe (Author), Patrícia Viviane Gaya (Author), André Brooking Negrão (Author), José Eduardo Krieger (Author), Alexandre Costa Pereira (Author), Paulo Caleb Júnior Lima Santos (Author)
Format: Book
Published: BMC, 2018-04-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_acadfd4de2b6432c80d904223e68a87a
042 |a dc 
100 1 0 |a Paulo Roberto Xavier Tomaz  |e author 
700 1 0 |a Juliana Rocha Santos  |e author 
700 1 0 |a Jaqueline Scholz  |e author 
700 1 0 |a Tânia Ogawa Abe  |e author 
700 1 0 |a Patrícia Viviane Gaya  |e author 
700 1 0 |a André Brooking Negrão  |e author 
700 1 0 |a José Eduardo Krieger  |e author 
700 1 0 |a Alexandre Costa Pereira  |e author 
700 1 0 |a Paulo Caleb Júnior Lima Santos  |e author 
245 0 0 |a Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women 
260 |b BMC,   |c 2018-04-01T00:00:00Z. 
500 |a 10.1186/s12881-018-0571-3 
500 |a 1471-2350 
520 |a Abstract Background The identification of variants in the nicotinic acetylcholine receptor (nAChR) subunit genes associated with smoking phenotypes are increasingly important for prevention and treatment of nicotine dependence. In the context of personalized medicine, the aims of this study were to evaluate whether cholinergic receptor nicotinic alpha 2 (CHRNA2), cholinergic receptor nicotinic alpha 3 (CHRNA3), cholinergic receptor nicotinic alpha 5 (CHRNA5) and cholinergic receptor nicotinic beta 3 (CHRNB3) polymorphisms were associated with nicotine dependence severity, and to investigate possible pharmacogenetics markers of smoking cessation treatment. Methods This study cohort enrolled 1049 smoking patients who received pharmacological treatment (varenicline, varenicline plus bupropion, bupropion plus/or nicotine replacement therapy). Smoking cessation success was considered for patients who completed 6 months of continuous abstinence. Fagerström test for nicotine dependence (FTND) and Issa situational smoking scores (Issa score) were analyzed for nicotine dependence. CHRNA2 (rs2472553), CHRNA3 (rs1051730), CHRNA5 (rs16969968 and rs2036527) and CHRNB3 (rs6474413) polymorphisms were genotyped by high resolution melting analysis. Results Females with GA and AA genotypes for CHRNA5 rs16969968 and rs2036527 polymorphisms had higher success rate in smoking cessation treatment: 44.0% and 56.3% (rs16969968), 41.5% and 56.5% (rs2036527), respectively, compared with carriers of the GG genotypes: 35.7% (rs16969968), 34.8% (rs2036527), (P = 0.03, n = 389; P = 0.01, n = 391). The GA or AA genotypes for the rs16969968 and rs2036527 were associated with higher odds ratio for success in women (OR = 1.63; 95% CI = 1.04 to 2.54; P = 0.03 and OR = 1.59, 95% CI = 1.02 to 2.48; P = 0.04; respectively). We did not find association of these polymorphisms with nicotine dependence related scores. Polymorphisms in the CHRNA2, CHRNA3 and CHRNB3 genes were not associated with the phenotypes studied. Conclusion CHRNA5 rs16969968 and rs2036527 were associated with higher success rate in the smoking cessation treatment in women. These findings might contribute to advances in personalized medicine. 
546 |a EN 
690 |a CHRNA5 
690 |a Nicotine dependence 
690 |a Smoking cessation 
690 |a Polymorphism 
690 |a Internal medicine 
690 |a RC31-1245 
690 |a Genetics 
690 |a QH426-470 
655 7 |a article  |2 local 
786 0 |n BMC Medical Genetics, Vol 19, Iss 1, Pp 1-8 (2018) 
787 0 |n http://link.springer.com/article/10.1186/s12881-018-0571-3 
787 0 |n https://doaj.org/toc/1471-2350 
856 4 1 |u https://doaj.org/article/acadfd4de2b6432c80d904223e68a87a  |z Connect to this object online.