Topical Therapeutic Options in Corneal Neuropathic Pain

Purpose of Review: Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component....

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Bibliographic Details
Main Authors: Jeremy Nortey (Author), David Smith (Author), Gerami D. Seitzman (Author), John A. Gonzales (Author)
Format: Book
Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
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Summary:Purpose of Review: Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component. We also describe possible mechanisms of action for such topical therapies.Recent Findings: Topical corticosteroids and blood-derived tear preparations can be helpful. Newer therapies, including topical lacosamide and low-dose naltrexone are emerging therapeutic options that may also be considered.Summary: Corneal neuropathic pain with a significant peripheral component may be managed with a variety of topical therapeutic options.
Item Description:1663-9812
10.3389/fphar.2021.769909