Effects of Acute Intravenous Administration of Pentamidine, a Typical hERG-Trafficking Inhibitor, on the Cardiac Repolarization Process of Halothane-Anesthetized Dogs

• Main Authors: Hirofumi Yokoyama (Author), Yuji Nakamura (Author), Hiroshi Iwasaki (Author), Yukitoshi Nagayama (Author), Kiyotaka Hoshiai (Author), Yoshitaka Mitsumori (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Although acute treatment of pentamidine does not directly modify any ionic channel function in the heart at clinically relevant concentrations, its continuous exposure can prolong QT interval. Recent in vitro studies have indicated that hERG trafficking inhibition may play an important ro...