Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells

• Main Authors: Angela P. Bastidas-Coral (Author), Astrid D. Bakker (Author), Behrouz Zandieh-Doulabi (Author), Cornelis J. Kleverlaan (Author), Nathalie Bravenboer (Author), Tim Forouzanfar (Author), Jenneke Klein-Nulend (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During the initial stages of bone repair, proinflammatory cytokines are released within the injury site, quickly followed by a shift to anti-inflammatory cytokines. The effect of pro- and anti-inflammatory cytokines on osteogenic differentiation of mesenchymal stem cells is controversial. Here, we i...