Genetic variation in UGT1A1 is not associated with altered liver biochemical parameters in healthy volunteers participating in bioequivalence trials

• Main Authors: Eva González-Iglesias (Author), Dolores Ochoa (Author), Manuel Román (Author), Paula Soria-Chacartegui (Author), Samuel Martín-Vilchez (Author), Marcos Navares-Gómez (Author), Alejandro De Miguel (Author), Pablo Zubiaur (Author), Andrea Rodríguez-Lopez (Author), Francisco Abad-Santos (Author), Jesús Novalbos (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Bioequivalence clinical trials are conducted in healthy volunteers whose blood tests should be within normal limits; individuals with Gilbert syndrome (GS) are excluded from these studies on suspicion of any liver disease, even if the change is clinically insignificant. GS is a benign...