Prickly Pear Betalain-Rich Extracts as New Promising Strategy for Intestinal Inflammation: Plant Complex vs. Main Isolated Bioactive Compounds
Recently, many studies have highlighted the health effects of betalains beyond their use as food dyes. The present study investigated betalain-rich extracts with different colors and their main bioactive compounds in order to provide first evidence as a new promising strategy for intestinal inflamma...
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Frontiers Media S.A.,
2021-09-01T00:00:00Z.
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| 001 | doaj_ad14f860a94d43dab6d5b9f8ac1a8b1e | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a A. Smeriglio |e author |
| 700 | 1 | 0 | |a C. De Francesco |e author |
| 700 | 1 | 0 | |a C. De Francesco |e author |
| 700 | 1 | 0 | |a M. Denaro |e author |
| 700 | 1 | 0 | |a D. Trombetta |e author |
| 245 | 0 | 0 | |a Prickly Pear Betalain-Rich Extracts as New Promising Strategy for Intestinal Inflammation: Plant Complex vs. Main Isolated Bioactive Compounds |
| 260 | |b Frontiers Media S.A., |c 2021-09-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2021.722398 | ||
| 520 | |a Recently, many studies have highlighted the health effects of betalains beyond their use as food dyes. The present study investigated betalain-rich extracts with different colors and their main bioactive compounds in order to provide first evidence as a new promising strategy for intestinal inflammation management. Prickly pear betalain-rich extracts, obtained by a QuEChERS method, have been characterized by LC-DAD-ESI-MS/MS analysis. The potential role of betanin, indicaxanthin, and prickly pear extracts in counteracting the antioxidant and anti-inflammatory events was evaluated by several in vitro cell-free and cell-based assays. Indicaxanthin and betanin represent the most abundant compounds (≥22.27 ± 4.50 and 1.16 ± 0.17 g/100 g dry extract, respectively). Prickly pear extracts showed the strongest antioxidant and anti-inflammatory activities with respect to the pure betalains both on in vitro cell-free and cell-based assays, demonstrating the occurrence of synergistic activity, without any cytotoxicity or alteration of the barrier systems. The release of reactive oxygen species (ROS) and key inflammatory markers (IL-6, IL-8, and NO) was strongly inhibited by both betalains and even more by prickly pear extracts, which showed a similar and sometimes better profile than the reference compounds trolox and dexamethasone in counteracting the IL-1β-induced intestinal inflammation. | ||
| 546 | |a EN | ||
| 690 | |a Opuntia ficus indica L. (Mill) | ||
| 690 | |a prickly pear | ||
| 690 | |a betalains | ||
| 690 | |a antioxidant activity | ||
| 690 | |a anti-inflammatory activity | ||
| 690 | |a Caco-2 cells | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 12 (2021) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2021.722398/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ad14f860a94d43dab6d5b9f8ac1a8b1e |z Connect to this object online. |