Antimicrobial Treatment on a Catheter-Related Bloodstream Infection (CRBSI) Case Due to Transition of a Multi-Drug-Resistant <i>Ralstonia mannitolilytica</i> from Commensal to Pathogen during Hospitalization
Despite its commonly overlooked role as a commensal, <i>Ralstonia mannitolilytica</i> becomes an emerging global opportunistic human pathogen and a causative agent of various infections and diseases. In respiratory illnesses, including cystic fibrosis and chronic obstructive pulmonary di...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2022-10-01T00:00:00Z.
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| Summary: | Despite its commonly overlooked role as a commensal, <i>Ralstonia mannitolilytica</i> becomes an emerging global opportunistic human pathogen and a causative agent of various infections and diseases. In respiratory illnesses, including cystic fibrosis and chronic obstructive pulmonary disease (COPD), <i>R. mannitolilytica</i> is also identified presumably as colonizer. In this study, one distinctive clone of <i>R. mannitolilytica</i> was firstly identified as colonizer for the first 20 days during hospitalization of a patient. It was then identified as a causative agent for catheter-related bloodstream infection with negative identification after effective treatment, verifying its transition from commensal to pathogen. In conclusion, we provide convincing evidence that during hospitalization of a patient, <i>R. mannitolilytica</i> transitioned from commensal to pathogen in the respiratory tract leading to catheter-related bloodstream infection (CRBSI). |
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| Item Description: | 10.3390/antibiotics11101376 2079-6382 |