Repurposing Treatment of Wernicke-Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile

• Main Authors: Vatsalya Vatsalya (Author), Fengyuan Li (Author), Jane Frimodig (Author), Khushboo S. Gala (Author), Shweta Srivastava (Author), Maiying Kong (Author), Vijay A. Ramchandani (Author), Wenke Feng (Author), Xiang Zhang (Author), Craig J. McClain (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coronavirus disease identified in 2019 (COVID-19) can be complicated by the Th17 cell-mediated IL-17 proinflammatory response. We tested if thiamine can effectively lower the Th17 response in a clinical study [Proinflammatory state in alcohol use disorder patients termed as disease controls (DC)] an...