Cytomegalovirus-associated biliary atresia
The pathogenesis of biliary atresia (BA) is propounded to be an immunological process, but the detailed mechanisms remain unclear. In recent studies with abnormal immunological findings, T cells have drawn attention in the mechanism of BA pathogenesis. Furthermore, cytomegalovirus (CMV) infection in...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2018-08-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_adea00e18b0d48f59dce335be5a60ca0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kazuki Kodo |e author |
| 700 | 1 | 0 | |a Kenichi Sakamoto |e author |
| 700 | 1 | 0 | |a Tomohiko Imai |e author |
| 700 | 1 | 0 | |a Takeshi Ota |e author |
| 700 | 1 | 0 | |a Mitsuru Miyachi |e author |
| 700 | 1 | 0 | |a Jun Mori |e author |
| 700 | 1 | 0 | |a Tomohiro Chiyonobu |e author |
| 700 | 1 | 0 | |a Tetsuya Imura |e author |
| 700 | 1 | 0 | |a Hajime Hosoi |e author |
| 245 | 0 | 0 | |a Cytomegalovirus-associated biliary atresia |
| 260 | |b Elsevier, |c 2018-08-01T00:00:00Z. | ||
| 500 | |a 2213-5766 | ||
| 500 | |a 10.1016/j.epsc.2018.02.002 | ||
| 520 | |a The pathogenesis of biliary atresia (BA) is propounded to be an immunological process, but the detailed mechanisms remain unclear. In recent studies with abnormal immunological findings, T cells have drawn attention in the mechanism of BA pathogenesis. Furthermore, cytomegalovirus (CMV) infection in BA patients resulted in elevated levels of helper T cells (Th1 and Th17) and reduction of regulatory T cells. Thus, CMV infection is considered as a cause of BA.We present the case of a 3-month-old boy who presented with intracerebral hemorrhage and finally died of liver failure. BA was diagnosed on autopsy and serum CMV-IgM was positive, but CMV antigen in the liver tissue was negative.Because CMV-associated BA has poor prognosis, compared with BA not associated with CMV, accurate classification of the type of BA is essential. Keywords: Biliary atresia, Cytomegalovirus, Cytomegalovirus-associated biliary atresia | ||
| 546 | |a EN | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 690 | |a Surgery | ||
| 690 | |a RD1-811 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pediatric Surgery Case Reports, Vol 35, Iss , Pp 17-20 (2018) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2213576618300150 | |
| 787 | 0 | |n https://doaj.org/toc/2213-5766 | |
| 856 | 4 | 1 | |u https://doaj.org/article/adea00e18b0d48f59dce335be5a60ca0 |z Connect to this object online. |