CARD9 as a potential target in cardiovascular disease
Matthew R Peterson, Samantha E Haller, Jun Ren, Sreejayan Nair, Guanglong He School of Pharmacy, University of Wyoming, College of Health Sciences, Laramie, WY, USA Abstract: Systemic inflammation and localized macrophage infiltration have been implicated in cardiovascular pathologies, including cor...
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| Main Authors: | , , , , |
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| Format: | Book |
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Dove Medical Press,
2016-11-01T00:00:00Z.
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| Summary: | Matthew R Peterson, Samantha E Haller, Jun Ren, Sreejayan Nair, Guanglong He School of Pharmacy, University of Wyoming, College of Health Sciences, Laramie, WY, USA Abstract: Systemic inflammation and localized macrophage infiltration have been implicated in cardiovascular pathologies, including coronary artery disease, carotid atherosclerosis, heart failure, obesity-associated heart dysfunction, and cardiac fibrosis. Inflammation induces macrophage infiltration and activation and release of cytokines and chemokines, causing tissue dysfunction by instigating a positive feedback loop that further propagates inflammation. Cytosolic adaptor caspase recruitment domain family, member 9 (CARD9) is a protein expressed primarily by dendritic cells, neutrophils, and macrophages, in which it mediates cytokine secretion. The purpose of this review is to highlight the role of CARD9 as a potential target in inflammation-related cardiovascular pathologies. Keywords: inflammation, heart failure, pressure-overload, hypertension |
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| Item Description: | 1177-8881 |