Usefulness of interferon-γ release assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province, China
Abstract Background Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness of the interferon-γ release assay (IGRA) for the diagnosis of smear-negative pulmonary and extra-pulmona...
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BMC,
2017-09-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_aeba1f9c20a543e2be05a168dcf7ec62 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Lei Ji |e author |
| 700 | 1 | 0 | |a Yong-Liang Lou |e author |
| 700 | 1 | 0 | |a Zhong-Xiu Wu |e author |
| 700 | 1 | 0 | |a Jin-Qin Jiang |e author |
| 700 | 1 | 0 | |a Xing-Li Fan |e author |
| 700 | 1 | 0 | |a Li-Fang Wang |e author |
| 700 | 1 | 0 | |a Xiao-Xiang Liu |e author |
| 700 | 1 | 0 | |a Peng Du |e author |
| 700 | 1 | 0 | |a Jie Yan |e author |
| 700 | 1 | 0 | |a Ai-Hua Sun |e author |
| 245 | 0 | 0 | |a Usefulness of interferon-γ release assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province, China |
| 260 | |b BMC, |c 2017-09-01T00:00:00Z. | ||
| 500 | |a 10.1186/s40249-017-0331-1 | ||
| 500 | |a 2049-9957 | ||
| 520 | |a Abstract Background Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness of the interferon-γ release assay (IGRA) for the diagnosis of smear-negative pulmonary and extra-pulmonary TB. Methods We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients (including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients), 113 extra-pulmonary TB patients, 81 patients with other pulmonary diseases and 100 healthy controls. Blood samples for the TB-Ab test and the TB-IGRA were collected, processed, and interpreted according to the manufacturer's protocol. Results The detection ratio of smear-positive pulmonary TB patients and smear-negative pulmonary TB patients were 90.8% (109 of 120) and 89.6% (241 of 269), respectively. There was no statistically significant difference of its performance between these two sample sets (P > 0.05). The detection ratio of positive TB patients and extra-pulmonary TB patients were 90.0% (350 of 389) and 87.6% (99 of 113), respectively, which was not significantly different (P > 0.05). Conclusions In this work, the total detection ratio using TB-IGRA was 89.4%, therefore TB-IGRA has diagnostic values in smear-negative pulmonary TB and extra-pulmonary TB diagnosis. | ||
| 546 | |a EN | ||
| 690 | |a Interferon-gamma release assay | ||
| 690 | |a Smear-negative pulmonary TB | ||
| 690 | |a Extra-pulmonary TB | ||
| 690 | |a Infectious and parasitic diseases | ||
| 690 | |a RC109-216 | ||
| 690 | |a Public aspects of medicine | ||
| 690 | |a RA1-1270 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Infectious Diseases of Poverty, Vol 6, Iss 1, Pp 1-5 (2017) | |
| 787 | 0 | |n http://link.springer.com/article/10.1186/s40249-017-0331-1 | |
| 787 | 0 | |n https://doaj.org/toc/2049-9957 | |
| 856 | 4 | 1 | |u https://doaj.org/article/aeba1f9c20a543e2be05a168dcf7ec62 |z Connect to this object online. |