Proximity Ligation Assay Detection of Protein-DNA Interactions-Is There a Link between Heme Oxygenase-1 and G-quadruplexes?

• Main Authors: Wojciech Krzeptowski (Author), Patryk Chudy (Author), Grzegorz Sokołowski (Author), Monika Żukowska (Author), Anna Kusienicka (Author), Agnieszka Seretny (Author), Agata Kalita (Author), Alicja Czmoczek (Author), Jakub Gubała (Author), Sonia Baran (Author), Damian Klóska (Author), Mateusz Jeż (Author), Jacek Stępniewski (Author), Krzysztof Szade (Author), Agata Szade (Author), Anna Grochot-Przęczek (Author), Alicja Józkowicz (Author), Witold N. Nowak (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G-quadruplexes (G4) are stacked nucleic acid structures that are stabilized by heme. In cells, they affect DNA replication and gene transcription. They are unwound by several helicases but the composition of the repair complex and its heme sensitivity are unclear. We found that the accumulation of G...