Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate

• Main Authors: Masaya Ishibashi (Author), Taku Fujimura (Author), Akira Hashimoto (Author), Takahiro Haga (Author), Kaoru Onami (Author), Akira Tsukada (Author), Yumi Kambayashi (Author), Takanori Hidaka (Author), Sadanori Furudate (Author), Ryoko Shimada (Author), Setsuya Aiba (Author)
• Format: Book
• Published: Karger Publishers, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m2 body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

Item Description

1662-6567
10.1159/000335999