Respirable controlled release polymeric colloid (RCRPC) of bosentan for the management of pulmonary hypertension: in vitro aerosolization, histological examination and in vivo pulmonary absorption
Bosentan is an endothelin receptor antagonist (ERA) prescribed for patients with pulmonary arterial hypertension (PAH). The oral delivery of bosentan possesses several drawbacks such as low bioavailability (about 50%), short duration of action, frequent administration, hepatotoxicity and systemic hy...
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Main Authors: | Lydia A. Hanna (Author), Emad B. Basalious (Author), Omaima N. ELGazayerly (Author) |
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Format: | Book |
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Taylor & Francis Group,
2017-01-01T00:00:00Z.
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