Supraspinal and Peripheral, but Not Intrathecal, σ1R Blockade by S1RA Enhances Morphine Antinociception

• Principais autores: Alba Vidal-Torres (Autor), Begoña Fernández-Pastor (Autor), Alicia Carceller (Autor), José Miguel Vela (Autor), Manuel Merlos (Autor), Daniel Zamanillo (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Sigma-1 receptor (σ1R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ1R antagonist widely used to study the role of σ1Rs. S1RA alone exerted antinociceptive effect in the formalin test in rats and increased noradrenaline levels in the spinal c...