Physiologically‐based pharmacokinetic model to predict doxorubicin and paclitaxel exposure in infants through breast milk

• Main Authors: David Damoiseaux (Author), Frédéric Amant (Author), Jos H. Beijnen (Author), Shelby Barnett (Author), Gareth J. Veal (Author), Alwin D. R. Huitema (Author), Thomas P. C. Dorlo (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Limited information is available concerning infant exposure and safety when breastfed by mothers receiving chemotherapy. Whereas defining distribution to breast milk is important to infer drug exposure, infant pharmacokinetics also determine to what extent the infant will be exposed to pote...