Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

• Main Authors: Nikunjkumar Patel (Author), James F. Clarke (Author), Farzaneh Salem (Author), Tariq Abdulla (Author), Frederico Martins (Author), Sumit Arora (Author), Eleftheria Tsakalozou (Author), Arran Hodgkinson (Author), Omid Arjmandi‐Tash (Author), Sinziana Cristea (Author), Priyanka Ghosh (Author), Khondoker Alam (Author), Sam G. Raney (Author), Masoud Jamei (Author), Sebastian Polak (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Physiologically‐based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption, distribution, metabolism, excretion characteristics, formulation attributes, and trial design or dosing regimen to mechanistically simula...