Antibiotic Resistance of Uropathogens Isolated from Patients Hospitalized in District Hospital in Central Poland in 2020

• Main Authors: Barbara Kot (Author), Agata Grużewska (Author), Piotr Szweda (Author), Jolanta Wicha (Author), Urszula Parulska (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antibiotics10040447; 2079-6382
• Keywords: urinary tract infection; uropathogenes; resistance to antibiotics; <i>Escherichia coli</i>; <i>Klebsiella pneumoniae</i>; <i>Proteus mirabilis</i>; Therapeutics. Pharmacology; RM1-950
• Source: Antibiotics, Vol 10, Iss 4, p 447 (2021)

The aim of this study was to determine antibiotic resistance patterns and the prevalence of uropathogenes causing urinary tract infections (UTIs) in patients hospitalized in January-June 2020 in central Poland. Antimicrobial susceptibility testing was performed using the disk-diffusion method. <i>Escherichia coli</i> (52.2%), <i>Klebsiella pneumoniae</i> (13.7%), <i>Enterococcus faecalis</i> (9.3%), <i>E. faecium</i> (6.2%), and <i>Proteus mirabilis</i> (4,3%) were most commonly isolated from urine samples. <i>E. coli</i> was significantly more frequent in women (58.6%) (<i>p</i> = 0.0089) and in the age group 0-18, while <i>K. pneumoniae</i> was more frequent in men (24.4%) (<i>p</i> = 0.0119) and in individuals aged 40-60 and >60. Gram-negative species showed resistance to ampicillin. <i>K. pneumoniae</i> were resistant to amoxicillin plus clavulanic acid (75.0%), piperacillin plus tazobactam (76.2%), cefotaxime (76.2%), cefuroxime (81.0%), ciprofloxacin (81.0%), and trimethoprim plus sulphamethoxazole (81.0%). Carbapenems were effective against all <i>E. coli</i> and <i>P. mirabilis</i>. Some <i>K. pneumoniae</i> (13.6%) produced metallo-β-lactamases (MBLs). <i>E. coli</i> (22.6%), <i>K. pneumoniae</i> (81.8%), and all <i>E. faecium</i> were multidrug-resistant (MDR). Some <i>E. coli</i> (26.2%), <i>K. pneumoniae</i> (63.6%), and <i>P. mirabilis</i> (14.3%) isolates produced extended-spectrum beta-lactamases (ESBL). Vancomycin-resistant <i>E. faecium</i> was also found. This study showed that the possibilities of UTIs therapy using available antibiotics become limited due to the increasing number of antibiotic-resistant uropathogens.