Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response

• Main Authors: Joey De Backer (Author), Darko Maric (Author), Karim Zuhra (Author), Annemie Bogaerts (Author), Csaba Szabo (Author), Wim Vanden Berghe (Author), David Hoogewijs (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite recent advances in melanoma treatment, there are still patients that either do not respond or develop resistance. This unresponsiveness and/or acquired resistance to therapy could be explained by the fact that some melanoma cells reside in a dedifferentiated state. Interestingly, this dediff...