Upregulation of Tolerogenic Pathways by the Hydrogen Sulfide Donor GYY4137 and Impaired Expression of H₂S-Producing Enzymes in Multiple Sclerosis

• Main Authors: Milica Lazarević (Author), Giuseppe Battaglia (Author), Bojan Jevtić (Author), Neda Djedovic (Author), Valeria Bruno (Author), Eugenio Cavalli (Author), Đorđe Miljković (Author), Ferdinando Nicoletti (Author), Miljana Momčilović (Author), Paolo Fagone (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to examine the in vitro effects of the slow-releasing H₂S donor GYY4137 on the immune cells involved in the pathogenesis of the central nervous system (CNS) autoimmune disease, multiple sclerosis (MS). GYY4137 specifically potentiated TGF-β expression...