Mechanical Ventilation Augments Poly(I:C)-Induced Lung Injury via a WISP1-Integrin β3-Dependent Pathway in Mice

• Main Authors: Shuqing Jin (Author), Zhixia Chen (Author), Xibing Ding (Author), Xiang Zhao (Author), Xi Jiang (Author), Yao Tong (Author), Timothy R Billiar (Author), Quan Li (Author)
• Format: Book
• Published: BMC, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Mechanical ventilation can improve hypoxemia, but can also cause the so-called ventilator-induced lung injury (VILI). Polyinosinic:polycytidylic acid (poly(I:C)), an analogue of natural double-strand RNA virus, can induce lung inflammation. The purpose of this study was to determine whether...