Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

• Main Authors: María Dolores Rodríguez-Pérez (Author), Juan Antonio López-Villodres (Author), María Monsalud Arrebola (Author), Esther Martín-Aurioles (Author), África Fernández-Prior (Author), Alejandra Bermúdez-Oria (Author), María Carmen Ríos (Author), José Pedro De La Cruz (Author), José Antonio González-Correa (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antiox10111783; 2076-3921
• Keywords: hydroxytyrosol; diabetes; nephropathy; virgin olive oil; Therapeutics. Pharmacology; RM1-950
• Source: Antioxidants, Vol 10, Iss 11, p 1783 (2021)

The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.