Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administrati...

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Main Authors: María Dolores Rodríguez-Pérez (Author), Juan Antonio López-Villodres (Author), María Monsalud Arrebola (Author), Esther Martín-Aurioles (Author), África Fernández-Prior (Author), Alejandra Bermúdez-Oria (Author), María Carmen Ríos (Author), José Pedro De La Cruz (Author), José Antonio González-Correa (Author)
Format: Book
Published: MDPI AG, 2021-11-01T00:00:00Z.
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042 |a dc 
100 1 0 |a María Dolores Rodríguez-Pérez  |e author 
700 1 0 |a Juan Antonio López-Villodres  |e author 
700 1 0 |a María Monsalud Arrebola  |e author 
700 1 0 |a Esther Martín-Aurioles  |e author 
700 1 0 |a África Fernández-Prior  |e author 
700 1 0 |a Alejandra Bermúdez-Oria  |e author 
700 1 0 |a María Carmen Ríos  |e author 
700 1 0 |a José Pedro De La Cruz  |e author 
700 1 0 |a José Antonio González-Correa  |e author 
245 0 0 |a Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect 
260 |b MDPI AG,   |c 2021-11-01T00:00:00Z. 
500 |a 10.3390/antiox10111783 
500 |a 2076-3921 
520 |a The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production. 
546 |a EN 
690 |a hydroxytyrosol 
690 |a diabetes 
690 |a nephropathy 
690 |a virgin olive oil 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 10, Iss 11, p 1783 (2021) 
787 0 |n https://www.mdpi.com/2076-3921/10/11/1783 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/b08b9c23e6194fb8abfcbdfb40ea79c8  |z Connect to this object online.