Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administrati...
Saved in:
Main Authors: | , , , , , , , , |
---|---|
Format: | Book |
Published: |
MDPI AG,
2021-11-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
LEADER | 00000 am a22000003u 4500 | ||
---|---|---|---|
001 | doaj_b08b9c23e6194fb8abfcbdfb40ea79c8 | ||
042 | |a dc | ||
100 | 1 | 0 | |a María Dolores Rodríguez-Pérez |e author |
700 | 1 | 0 | |a Juan Antonio López-Villodres |e author |
700 | 1 | 0 | |a María Monsalud Arrebola |e author |
700 | 1 | 0 | |a Esther Martín-Aurioles |e author |
700 | 1 | 0 | |a África Fernández-Prior |e author |
700 | 1 | 0 | |a Alejandra Bermúdez-Oria |e author |
700 | 1 | 0 | |a María Carmen Ríos |e author |
700 | 1 | 0 | |a José Pedro De La Cruz |e author |
700 | 1 | 0 | |a José Antonio González-Correa |e author |
245 | 0 | 0 | |a Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect |
260 | |b MDPI AG, |c 2021-11-01T00:00:00Z. | ||
500 | |a 10.3390/antiox10111783 | ||
500 | |a 2076-3921 | ||
520 | |a The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production. | ||
546 | |a EN | ||
690 | |a hydroxytyrosol | ||
690 | |a diabetes | ||
690 | |a nephropathy | ||
690 | |a virgin olive oil | ||
690 | |a Therapeutics. Pharmacology | ||
690 | |a RM1-950 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Antioxidants, Vol 10, Iss 11, p 1783 (2021) | |
787 | 0 | |n https://www.mdpi.com/2076-3921/10/11/1783 | |
787 | 0 | |n https://doaj.org/toc/2076-3921 | |
856 | 4 | 1 | |u https://doaj.org/article/b08b9c23e6194fb8abfcbdfb40ea79c8 |z Connect to this object online. |