Oral Bioavailability Enhancement of Vancomycin Hydrochloride with Cationic Nanocarrier (Leciplex): Optimization, In Vitro, Ex Vivo, and In Vivo Studies

• Auteurs principaux: Menna M. Abdellatif (Auteur), Sara Mohamed Ahmed (Auteur), Mohamed A. El-Nabarawi (Auteur), Mahmoud Teaima (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

To explore the performance of the cationic nanocarrier leciplex (LPX) in escalating the oral bioavailability of vancomycin hydrochloride (VAN) by promoting its intestinal permeability. With the aid of a D-optimal design, the effect of numerous factors, including lipid molar ratio, cationic surfactan...