Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies

• Main Authors: Hamad M. Alkahtani (Author), Mohammed M. Alanazi (Author), Fadilah Sfouq Aleanizy (Author), Fulwah Yahya Alqahtani (Author), Ali Alhoshani (Author), Fawaz E. Alanazi (Author), Abdulrahman A. Almehizia (Author), Ashraf N. Abdalla (Author), Mashael G. Alanazi (Author), Adel S. El-Azab (Author), Alaa A.-M (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of 5,5-diphenylhydantoin derivatives containing benzylidene or isatin (4-19) was synthesized. Their anticancer activity against HeLa, a cervical cancer cell line, A549, a lung cancer cell line, and MDA-MB-231, a breast cancer cell line, was evaluated. Compounds 13, 16, 17 and 18 exhibit...