Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches-An Overview
Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can prov...
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| Main Authors: | , , , |
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| Format: | Book |
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MDPI AG,
2020-08-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_b10b50be350f4923bb7bf0cdaa18a35f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Natalia Carballo-Pedrares |e author |
| 700 | 1 | 0 | |a Isaac Fuentes-Boquete |e author |
| 700 | 1 | 0 | |a Silvia Díaz-Prado |e author |
| 700 | 1 | 0 | |a Ana Rey-Rico |e author |
| 245 | 0 | 0 | |a Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches-An Overview |
| 260 | |b MDPI AG, |c 2020-08-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics12080752 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches. | ||
| 546 | |a EN | ||
| 690 | |a musculoskeletal tissue | ||
| 690 | |a cardiovascular tissue | ||
| 690 | |a wound healing | ||
| 690 | |a nervous tissue | ||
| 690 | |a gene therapy | ||
| 690 | |a controlled delivery | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 12, Iss 8, p 752 (2020) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/12/8/752 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/b10b50be350f4923bb7bf0cdaa18a35f |z Connect to this object online. |