Effect of the combination of mexidol and diclofenac sodium on exudative inflammation in rats after ten-day preventive oral administration
In rats with carrageenan-induced paw edema, diclofenac sodium significantly reduces exudation after ten-day preventive oral administration at a dose of 10 mg/kg but not 5 mg/kg. Mexidol at a dose of 100 mg/kg in combination with diclofenac sodium at a dose of 5 mg/kg (preventively orally, during 10...
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| Main Authors: | , , , |
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| Format: | Book |
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LLC "Publisher OKI",
2022-05-01T00:00:00Z.
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| Summary: | In rats with carrageenan-induced paw edema, diclofenac sodium significantly reduces exudation after ten-day preventive oral administration at a dose of 10 mg/kg but not 5 mg/kg. Mexidol at a dose of 100 mg/kg in combination with diclofenac sodium at a dose of 5 mg/kg (preventively orally, during 10 days, once a day) reduces paw edema during the first two out of four hours of its recording compared with the control group. However, ten-day preventive oral administration of mexidol at a dose of 100 mg/kg (once a day) increases the severity of carrageenan-induced paw edema in rats at four hours after the injection of the phlogogen. |
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| Item Description: | 2587-7836 2686-8830 10.37489/2587-7836-2022-1-14-19 |